My 3-month-old merle Great Dane puppy's eyes look like they're different colors sometimes, but it's hard to tell for sure. One side of his face is white and the other is merle grey, so it may be an optical illusion. I try to get a good look into his eyes on this video.
Mismatched eyes are a fault under the U.S. Great Dane Breed Standard, which states: “In harlequins… eyes of different colors … are permitted but not desirable.”
However, lots of people who meet Princeton seem happy and excited at the thought that his eyes may be different colors.
I’ve heard that a dog’s eye color is not set until it is four months old, so Princeton’s eyes are still changing. Hey, we think he looks handsome, no matter what!
Princeton (born April 24, 2008) is a happy, fun-loving Great Dane. He came to us from a breeder when he was 8 weeks old. He was born through a love match (unplanned breeding) of two Harlequins. His beautiful coloring is called “merle mantle” or Merlequin. He is a purebred AKC-registered Dane with champion European lines.